Clinical significance of hepatitis B virus core antigen (HBcAg) and core antibod

        Its meaning:

        (1) acute hepatitis B in HBsAg after the emergence of alanine aminotransferase (ALT) in the peak, can be measured in the serum anti -HBc, the first IgM -HBc, which is an important marker of hepatitis B virus acute or recent infection. The positive reaction of chronic hepatitis was also positive. About 6-12 months later, replaced by anti -HBcIgG, sustainable for many years does not fade. Anti -HBcIgM and IgG have continued to exist, often appear chronic process;

        (2) various types of chronic HBsAg carriers, in the serum can be detected in the high titer of anti -HBc;

        (3) the significance of single anti -HBc is still not completely clear. May be a sign of infection; the disappearance of HBsAg and anti -HBs has not yet appeared the so-called "window period"; anti HBc passive transfer: transfused blood products positive anti -HBc injection by HBV, the infected person's blood immune reaction preparation of hepatitis B immune globulin showed single positive anti -HBc. If anti -HBc positive, the blood may still be contagious. Hepatitis B virus particles in serum by detergent treatment, can make the release of internal components, known as the HBcAg. of the corresponding antibody called anti -HBc. There was no free HbcAg in the peripheral blood, and there was only the liver cell nucleus. So, HBcAg (+) often indicates that there is hepatitis B virus particles, there is contagious. HbcAg positive prognosis is poor. Negative prognosis is good. Anti -HBc is an indicator of the prevalence of HBV infection, and the total antibody of hepatitis B virus core antigen.