The first treatment of hepatitis B vaccine into clinical stage in China

        Before the day, Professor Xie Qing, Shanghai Second Medical University affiliated Ruijin hospital, Professor Xie Qing presided over the completion of the study of the mechanism of liver cell injury and treatment intervention by the results of identification. Experts believe that the study has innovative, to reach the international advanced level. The research paper was published in the Journal Hepatology, the most authoritative academic journal in the field of international liver disease research.

        Hepatocyte injury is a complex biological process mediated by multiple factors, which is closely related to the apoptosis of hepatocytes. Professor Xie Qing after 6 years of exploration, the first studies the various causes of liver cell apoptosis (death receptor and mitochondrial damage and endoplasmic reticulum stress) expression and regulation of genes, find key genes and therapeutic targets in different apoptosis pathway, but also proved the close relationship between liver cells apoptosis and liver cell damage and necrosis, the liver cell apoptosis is a prerequisite for liver cell necrosis. The study on damage of intracellular calcium homeostasis induced endoplasmic reticulum stress as the experimental model, the effects of calcium signal on the activation of Caspase12 proteases, provides a new idea for the treatment of endoplasmic reticulum stress related diseases. They found the chest deoxycholic acid anti liver cell apoptosis is a new mechanism for apoptosis gene Caspase 3 design and synthesis of the ribozyme can has a blocking effect on the apoptosis of liver cells and neuronal cells.

        Xie Qing for a number of effective target site, the design of drug intervention, liver cell injury and cell gene intervention intervention strategies, especially from the previous single drug treatment of diseases of liver cell injury model, the establishment of a diversified treatment system and achieved good results