Pathological cause of liver cirrhosis

        Pathologic classification

        Due to liver cirrhosis etiology, severity of inflammation and disease development, can present different pathological types, are still used to determine the pathological classification of hepatobiliary International Conference in 1974, according to the nodule size, shape was divided into 4 types.

        1, small nodular cirrhosis: nodule size is more uniform, generally in 3 ~ 5mm, the maximum not more than 1cm, fibrous septum is fine, the size of the false small, this type of cirrhosis is the most common.

        2, large tuberous sclerosis: nodular coarse, and vary in size, diameter in 1 ~ 3cm, with large nodules, a maximum diameter of 3 ~ 5cm, were composed of a plurality of leaflets and fibrous septa width is not a generally wide, pseudolobule ranging in size, the type of cirrhosis caused by large hepatic necrosis.

        3, large and small nodules mixed cirrhosis: for the above two types of mixed type, large nodules and small nodules of roughly equal proportions, this type of cirrhosis is also a lot of see.

        4, not completely separated from cirrhosis: also known as regenerative nodules unobviousness cirrhosis, characterized by fibrous hyperplasia significantly, extending to the lobule, but not completely separated hepatic lobules; fibrous tissue can be wrapped around a plurality of hepatic lobules formed larger centrilobular nodules, nodules were not regenerated. The etiology of this type in our country mainly for schistosomiasis.

Pathogeny

        Many causes of cirrhosis, can be divided into viral hepatitis cirrhosis and alcoholic cirrhosis, metabolic liver cirrhosis, biliary cirrhosis, hepatic venous obstruction of hepatic cirrhosis and autoimmune cirrhosis, toxins and drugs of liver cirrhosis, malnutrition, cirrhosis, cryptogenic cirrhosis etc..

        1, viral hepatitis

At present in China, especially chronic hepatitis B and hepatitis C, viral hepatitis is the main cause of portal cirrhosis.

        2, alcohol poisoning

Long term heavy drinking, is one of the factors that cause cirrhosis.

        3, nutritional disorders

Most scholars acknowledge that malnutrition can reduce the resistance of hepatocytes to toxic and infectious factors, and become an indirect cause of cirrhosis.

        4, industrial poisons or drugs

Prolonged or repeated exposure to pesticides containing arsenic, phosphorus, carbon tetrachloride, chloroform, or long-term use of certain drugs such as bisatin, isoniazid, Xin Kefen, tetracycline, methotrexate, methyldopa, can produce toxic or drug-induced hepatitis, leading to liver cirrhosis. Aflatoxin can also cause liver cell damage, cause liver cirrhosis.

        5, circulatory disorder

Chronic congestive heart failure, chronic constrictive pericarditis can make liver congestion caused by long-term hypoxia, liver cell necrosis and fibrosis, called silting hemorrhagic liver cirrhosis, also known as cardiac cirrhosis.

        6, metabolic disorders

Such as hemochromatosis and hepatolenticular degeneration (also known as Wilson disease).

        7, cholestasis

Extrahepatic bile duct obstruction or intrahepatic cholestasis bilirubin high concentration on liver cell injury can happen for a long time, intrahepatic cholestasis caused by liver cirrhosis, called primary biliary cirrhosis, extrahepatic bile duct obstruction caused by said secondary biliary cirrhosis.

        8, schistosomiasis

When the eggs of schistosomiasis stimulate hyperplasia of connective tissue in the portal area become schistosomiasis liver fibrosis can cause portal hypertension significantly, also known as schistosomiasis cirrhosis.

        9, the reason is unknown

Some of the causes of cirrhosis are unknown.